The foundations of our scientific approach to cancer, Tumor Reversion, rest on 2 major pillars : revertant cells and the reversion engine.
Revertant cells are the models of Tumor Reversion, and are isolated from various cancer cell lines through proprietary technologies.
The reversion engine or mechanism consists of the genes that are responsible for tumor reversion, and which are identified by differential gene expression analysis between cancer cells and revertant cells.
To date, various model systems for Tumor Reversion have been conceived, namely from human cancer cell lines of hematopoietic origin and from solid tumors. For the first time, we have isolated and cloned revertant cells from breast cancer cell lines.
We have also succeeded in identifying over 200 genes involved in the process of Tumor Reversion. The list of those differentially expressed genes includes receptors, growth factors, known oncogenes, as well as a large group of genes involved in protein synthesis and degradation.
These data suggest that tumor reversion can be defined at the molecular level not just as the reversal of malignant transformation, but as a biological process in its own right, involving a cellular reprogramming process leading to suppression of tumorigenicity.